Michael.lanzer@med.uni-heidelberg Telephone + 49 6221 56 78 45 Fax + 49 6221 56 46 43 Insitution Heidelberg University Medical School (UK-HDL) Address Hygiene-Institute GERMANY Home Page http://www.uni-heidelberg.de
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Professor Michael LanzerThe malaria group of Michael Lanzer has a long history on studies related to the biology and pathogenicity of Plasmodium falciparum and Plasmodium vivax. Important contributions to the field include: i) the generation of YAC clones and cloning of entire P. falciparum and P. vivax chromosomes; ii) the genomic mapping of var genes; iii) functional knock-outs of var genes; iv) the identification of the STEVOR gene family in P. falciparum and the vir gene family in P. vivax; v) transfection of P. vivax; demonstration that polymorphisms within PfMDR1 affects the substrate specificity of this transporter for antimalarial drugs. Recently, they have begun to investigate the mechanisms underpinning sorting and trafficking of P. falciparum-encoded proteins to destinations within the host erythrocyte. Other work conducted by the laboratory includes the investigation of the modes of action of antimalarial drugs and drug resistance mechanisms. |
